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References and Links to Papers

Publications: Publications


​As collaborators:

  • Karreman MA, Bauer AT, [...], Goetz JG, Schwab Y, Wick W, Winkler F. Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization. Cancer Research. 2023. doi:10.1158/0008-5472.CAN-22-3964


  • Garcia-Leon MJ, Lefebvre O, Follain G, [...] Mangin PH, Goetz JG. Platelets favor the outgrowth of established metastases. BioRxiv Preprint. 2022. doi:10.1101/2022.10.28.514195

  • Mary B, Asokan N, Jerabkova-Roda K, [...], Goetz JG, Hyenne V. Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis. BioRxiv Preprint. 2022. doi:10.1101/2022.12.19.521008

  • Peralta M, Osmani N, Goetz JG. Circulating tumor cells: Towards mechanical phenotyping of metastasis. iSciences. 2022. doi:10.1016/j.isci.2022.103969


  • Jerabkova-Roda K, Dupas A, Osmani N, Hyenne V, Goetz JG. Circulating extracellular vesicles and tumor cells: sticky partners in metastasis. Trends in Cancer. 2022. doi:10.1016/j.trecan.2022.05.002

  • Mittelheisser V, [...], Goetz JG, [...] Detappe A. Optimal Physicochemical Properties of Antibody–Nanoparticle Conjugates for Improved Tumor Targeting. Advanced Materials. 2022. doi:10.1002/adma.202110305

  • Hyenne V, Goetz JG & Osmani N. Liquid Biopsies: Flowing Biomarkers. Microfluidics and Biosensors in Cancer Research pp 341–368. doi:10.1007/978-3-031-04039-9_14

​As collaborators:

  • André-Grégoire, G., [...], Hyenne V, Goetz JG, Bidère N, Gavard J. Inhibition of the pseudokinase MLKL alters extracellular vesicle release and reduces tumor growth in glioblastoma. iScience. 25, 105118. 2022. doi:10.1016/j.isci.2022.105118

  • Adam A, Harlepp C, [...], Goetz JG, [...], Mertz D. Core-shell iron oxide@stellate mesoporous silica for combined near-infrared photothermia and drug delivery: Influence of pH and surface chemistry. Colloids and Surfaces A. Volume 640. 2022. doi:10.1016/j.colsurfa.2022.128407



EMBO | EMBL Symposium  ‘Defining and defeating metastasis
Poster Prize for her work on "Biphasic contribution of platelets to metastasis"


  • Follain G, Osmani N, Gensbittel V, [...], Goetz JG. Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells. Sci Rep. 2021;11(1):13144. doi:10.1038/s41598-021-92515-2

  • Ghoroghi S, Mary B, Larnicol A, [...], Goetz JG, Hyenne V. Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. Elife. 2021;10:1-29. doi:10.7554/eLife.61539

  • Gensbittel V, Kräter M, Harlepp S, Busnelli I, Guck J, Goetz JG. Mechanical Adaptability of Tumor Cells in MetastasisDevelopmental Cell. 2021. doi:10.1016/j.devcel.2020.10.011


  • Colin F, Gensbittel V, Goetz JG. Biomechanics: a driving force behind metastatic progression. Comptes Rendus Biol. 2021;344(3):249-262. doi:10.5802/crbiol.62

  • Ghoroghi S, Mary B, Asokan N, Goetz JG, Hyenne V. Tumor extracellular vesicles drive metastasis (it’s a long way from home). FASEB BioAdvances. 2021;3(11):930-943. doi:10.1096/fba.2021-00079

  • Osmani N, Follain G, Gensbittel V, Garcia-Leon MJ, Harlepp S, Goetz JG. Probing Intravascular Adhesion and Extravasation of Tumor Cells with Microfluidics. In: Methods in Molecular Biology. Vol 2294. Humana Press Inc.; 2021:111-132. doi:10.1007/978-1-0716-1350-4_8

  • Colin F, Schauer K, Hamiche A, [...], Schultz P, Goetz JG. The NANOTUMOR consortium – Towards the Tumor Cell Atlas. Biol Cell. 2021;113(6):boc.202000135. doi:10.1111/boc.202000135

  • Gaudin R, Goetz JG. Tracking Mechanisms of Viral Dissemination In Vivo. Trends Cell Biol. 2021;31(1):17-23. doi:10.1016/j.tcb.2020.09.005

  • Gensbittel V, Busnelli I, Osmani N, Goetz JG. Nanoluminal Signaling Shapes Collective Metastasis. Trends in Cancer. 2021;7(1):9-11. doi:10.1016/j.trecan.2020.11.003

  • Mary B, Ghoroghi S, Goetz JG, Hyenne V. Les vésicules extracellulaires tumorales favorisent la formation de niches pré-métastatiques. Médecine/Sciences. 2021 ; 37 : 1116-8. doi:10.1051/medsci/2021203

As collaborators

  • Verweij, F, [...], Goetz JG, Hyenne V, [...], Peinado H. The power of imaging to understand extracellular vesicle biology in vivo. Nature Methods. 2021. doi:10.1038/s41592-021-01206-3

  • Murphy KJ, Reed DA, Vennin C, [...], Timpson P. Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Sci Adv. 2021;7(40):22. doi:10.1126/sciadv.abh0363

  • Gaudin R, Goetz JG. Tracking Mechanisms of Viral Dissemination In Vivo. Trends in Cell Biology. 2021. doi:10.1016/j.tcb.2020.09.005

  • Liu F, Niko Y, Bouchaala R, [...] Klymchenko A. Drug‐Sponge Lipid Nanocarrier for in Situ Cargo Loading and Release Using Dynamic Covalent Chemistry. Angew Chemie Int Ed. 2021;60(12):6573-6580. doi:10.1002/anie.202014259

  • Belcastro E, Rehman AU, Remila L, [...] Schini-Kerth VB. Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells. Nanomedicine Nanotechnology, Biol Med. 2021;34:102379. doi:10.1016/j.nano.2021.102379


  • Follain G, Herrmann D, Harlepp S, [...], Timpson P, Goetz JG. Fluids and their mechanics in tumour transit: shaping metastasis. Nat Rev Cancer. 2020;20(2):107-124. doi:10.1038/s41568-019-0221-x

  • Mary B, Ghoroghi S, Hyenne V, Goetz JG. Live tracking of extracellular vesicles in larval zebrafish. In: Methods in Enzymology. Vol 645. Academic Press; 2020:243-275. doi:10.1016/bs.mie.2020.07.013

  • Follain G, Gensbittel V, Mary B, [...], Goetz JG. Influence de la mécanique des fluides sur la formation des métastases. médecine/sciences. 2020;36(10):872-878. doi:10.1051/medsci/2020158

  • Krummel M, Hu K, de Vries EGE, Goetz JG, et al. Visualizing Cancer. Cancer Cell. 2020;38(6):753-756. doi:10.1016/j.ccell.2020.11.014

    As collaborators


  • Perro M, Goetz JG, A Peixoto. Intra-vital microscopy. Imaging from Cells to Animals in Vivo, Book Chapter 2. ISBN 9781138041097

  • Mittelheisser V, Banerjee M, Pivot X, Charbonnière LJ, Goetz JG, Detappe A. Leveraging Immunotherapy with Nanomedicine. Adv Ther. 2020;3(12):2000134. doi:10.1002/adtp.202000134

  • Li B, Harlepp S, Gensbittel V, [...], Mertz D. Near infra-red light responsive carbon nanotubes@mesoporous silica for photothermia and drug delivery to cancer cells. Mater Today Chem. 2020;17. doi:10.1016/j.mtchem.2020.100308

  • Mertz D, Harlepp S, Goetz JG, [...], Hébraud A. Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications. Adv Ther. 2020;3(2):1900143. doi:10.1002/adtp.201900143


Vincent HYENNE


Jacky G. GOETZ

Grand Prix de Cancérologie de la Fondation Simone et Cino Del Duca de l'Institut de France - 2020

Prix Ruban Rose Avenir - 2020



Prix Bettencourt pour les
jeunes chercheurs - 2020


  • Osmani N, Follain G, García León MJ, [...], Goetz JG. Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest. Cell Rep. 2019;28(10):2491-2500.e5. doi:10.1016/j.celrep.2019.07.102

  • Hyenne V, Ghoroghi S, Collot M, [...], Goetz JG. Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo. Dev Cell. 2019;48(4):554-572.e7. doi:10.1016/j.devcel.2019.01.014

  • Verweij FJ, Hyenne V, Van Niel G, Goetz JG. Extracellular Vesicles: Catching the Light in Zebrafish. Trends Cell Biol. 2019;29(10):770-776. doi:10.1016/j.tcb.2019.07.007

  • Osmani N, Goetz JG. Multiscale Imaging of Metastasis in Zebrafish. Trends in Cancer. 2019;5(12):766-778. doi:10.1016/j.trecan.2019.10.003

    As collaborators


  • Verweij FJ, Revenu C, Arras G, [...] van Niel G. Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo. Dev Cell. 2019;48(4):573-589.e4. doi:10.1016/j.devcel.2019.01.004

  • San Juan BP, Garcia-Leon MJ, Rangel L, Goetz JG, Chaffer CL. The Complexities of Metastasis. Cancers (Basel). 2019;11(10):1575. doi:10.3390/cancers11101575

  • Hetmanski JHR, de Belly H, Busnelli I, [...] Caswell PT. Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration. Dev Cell. 2019;51(4):460-475.e10. doi:10.1016/j.devcel.2019.09.006

  • Ayala-Nunez NV, Follain G, Delalande F, [...] Goetz JG, Gaudin R. Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells. Nat Commun. 2019;10(1):4430. doi:10.1038/s41467-019-12408-x

  • Perton F, Harlepp S, Follain G, [...], Mertz D. Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo. J Colloid Interface Sci. 2019;542:469-482. doi:10.1016/j.jcis.2019.01.098


  • Follain G, Osmani N, Azevedo AS, [...], Goetz JG. Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells. Dev Cell. 2018;45(1):33-52.e12. doi:10.1016/j.devcel.2018.02.015

  • Hyenne V, Labouesse M, Goetz JG. The Small GTPase Ral orchestrates MVB biogenesis and exosome secretion. Small GTPases. 2018;9(6):445-451. doi:10.1080/21541248.2016.1251378

  • Goetz JG. Exploiting Anatomical Landmarks for Efficient In Vivo CLEM. Trends Biochem Sci. 2018;43(10):744-747. doi:10.1016/j.tibs.2018.08.003

  • Follain G, Osmani N, Fuchs C, Allio G, Harlepp S, Goetz JG. Using the Zebrafish Embryo to Dissect the Early Steps of the Metastasis Cascade. In: Methods in Molecular Biology. Vol 1749. Humana Press Inc.; 2018:195-211. doi:10.1007/978-1-4939-7701-7_15

  • Goetz JG. Metastases go with the flow. Science (80- ). 2018;362(6418):999-1000. doi:10.1126/science.aat9100

  • Chaffer CL, Goetz JG. CD44 Orchestrates Metastatic Teamwork. Dev Cell. 2018;47(6):691-693. doi:10.1016/j.devcel.2018.11.038

  • Follain G, Goetz JG. Synergistic Mechano-Chemical Sensing by Vascular Cilia. Trends Cell Biol. 2018;28(7):507-508. doi:10.1016/j.tcb.2018.04.005

  • Mammadova-Bach E, [...], Goetz JG, Orend G, Lefebvre O. Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biol Cell. 2018;110(8):178-195. doi:10.1111/boc.201800007

    As collaborators

  • Ezzoukhry Z, Henriet E, Cordelières FP, [...], Saltel F.. Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation. Nat Commun. 2018;9(1):2031. doi:10.1038/s41467-018-04461-9

  • Osmani N, Pontabry J, Comelles J, [...], Labouesse M. An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse. Spang A, ed. Mol Biol Cell. 2018;29(4):435-451. doi:10.1091/mbc.E17-06-0356

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