GOETZLAB

for Tumor Biomechanics

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RESEARCH AXIS

Biomechanics is a key component of the metastatic cascade:
Our laboratory focuses on the late stages of this process, namely dissemination, arrest and extravasation of circulating cancer cells (CTCs), as well as the importance of factors secreted by the primary tumor,
in particular extracellular vesicles (EVs). This is articulated around four major axes.

FORCE AXIS

Body fluids and their impacts on tumor progression and metastatic dissemination
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Study of circulating tumor cells (CTCs)

G. Follain & al. (2021) - Sci. Reports
N. Osmani & al. (2019) - Cell Reports
G. Follain & al. (2018) - Dev. Cell
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Gensbittel & al. (2020) - Dev. Cell
G. Follain & al. (2020) - Nat. Cancer Rev

EXPLORE AXIS

Role of extracellular vesicles (EVs, exosomes in particular) during the metastatic process
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Formation of
pre-metastatic niches

Ghoroghi & al. (2021) - eLife
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V. Hyenne & al. (2019) - Dev. Cell
Verweij & al. (2019) - Trends in Cell Bio.

TREAT AXIS

Impact of blood platelets during the metastatic process, particularly their interplay with CTCs
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Leveraging immunotherapy with nanomedicine

V. Mittelheiser & al. (2020) - Adv. Thera.
in coll. with A. Detappe
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B. P. San Juan & al. (2019) - Cancers
in coll. with C. L. Chaffer

NANOTUMOR

Coordination of the NanoTumor Consortium, initiated on Dec. 2019
and until May 2023
(in coll. with P. Schultz & al.)
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Towards the tumor cell atlas

F. Colin & al. (2021) - Bio. of the Cell
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NanoTumor Website

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CONTACT US

Thank you for your interest in our research.
Get in touch with us for any questions or comments regarding our work, publications and open positions

Jacky G. Goetz - GoetzLab Members

CRBS – Centre de Recherche en Biomédecine de Strasbourg
GoetzLab - U1109 - 5ème étage
1, rue Eugène Boeckel, 67000 Strasbourg

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