Understanding the mechanisms & mechanics
of tumor metastasis & dissemination
Welcome to the
TUMOR BIOMECHANICS LAB
About the
TUMOR BIOMECHANICS
LAB
Our lab is interested in dissecting the
mechanics and mechanics
of tumor dissemination and metastatasis
What makes
CANCER so LETHAL ?
It grows & gains strength
It invades locally and spreads throughout the body
It uses body fluids to colonize distant and vital organs
Check out a recent
documentary about the
TUMOR
BIOMECHANICS
LAB
Sponsored by INSERM & SBCF
Created by Les Explorers
RESEARCH AXIS
Biomechanics is a key component of the metastatic cascade:
Our laboratory focuses on the late stages of this process, namely dissemination, arrest and extravasation of circulating cancer cells (CTCs), as well as the importance of factors secreted by the primary tumor,
in particular extracellular vesicles (EVs). This is articulated around four major axes.
FORCE AXIS
Body fluids and their impacts on tumor progression and metastatic dissemination
-
Study of circulating tumor cells (CTCs)
G. Follain & al. (2021) - Sci. Reports
N. Osmani & al. (2019) - Cell Reports
G. Follain & al. (2018) - Dev. Cell
-
Gensbittel & al. (2020) - Dev. Cell
G. Follain & al. (2020) - Nat. Cancer Rev
EXPLORE AXIS
Role of extracellular vesicles (EVs, exosomes in particular) during the metastatic process
-
Formation of
pre-metastatic niches
Mary & al. (2023) - EMBO Rep
Ghoroghi & al. (2021) - eLife
V. Hyenne & al. (2019) - Dev. Cell
-
Welsh & al. (2024) - JEV
Ghoroghi & al. (2021) - FASEB Bioadv.
Verweij & al. (2021) - Nat. Methods
Verweij & al. (2019) - Trends in Cell Bio.
TREAT AXIS
Impact of blood platelets during the metastatic process, particularly their interplay with CTCs
-
Leveraging immunotherapy with nanomedicine
Garcia-Leon & al. (2024) - Nat. comm.in coll. with P. Mangin
V. Mittelheiser & al. (2020) - Adv. Thera.
in coll. with A. Detappe
-
B. P. San Juan & al. (2019) - Cancers
in coll. with C. L. Chaffer
NANOTUMOR
Coordination of the NanoTumor Consortium, initiated on Dec. 2019
and until May 2023
(in coll. with P. Schultz & al.)
-
Towards the tumor cell atlas
F. Colin & al. (2021) - Bio. of the Cell
-
NanoTumor Website
LATEST NEWS
CONTACT US
Thank you for your interest in our research.
Get in touch with us for any questions or comments regarding our work, publications and open positions
Jacky G. Goetz - GoetzLab Members
CRBS – Centre de Recherche en Biomédecine de Strasbourg
GoetzLab - U1109 - 5ème étage
1, rue Eugène Boeckel, 67000 Strasbourg