Dissecting the biomechanical events underlying tumor invasion, angiogenesis and metastasis
Biomechanics is a key component of the metastatic cascade:
Our laboratory focuses on the late stages of this process, namely dissemination, arrest and extravasation of circulating cancer cells (CTCs), as well as the importance of factors secreted by the primary tumor,
in particular extracellular vesicles (EVs). This is articulated around four major axes.
Body fluids and their impacts on tumor progression and metastatic dissemination
Study of circulating tumor cells (CTCs)
G. Follain & al. (2021) - Sci. Reports
N. Osmani & al. (2019) - Cell Reports
G. Follain & al. (2018) - Dev. Cell
Gensbittel & al. (2020) - Dev. Cell
G. Follain & al. (2020) - Nat. Cancer Rev
Role of extracellular vesicles (EVs, exosomes in particular) during the metastatic process
Ghoroghi & al. (2021) - eLife
V. Hyenne & al. (2019) - Dev. Cell
Verweij & al. (2019) - Trends in Cell Bio.
Impact of blood platelets during the metastatic process, particularly their interplay with CTCs
Leveraging immunotherapy with nanomedicine
V. Mittelheiser & al. (2020) - Adv. Thera.
in coll. with A. Detappe
B. P. San Juan & al. (2019) - Cancers
in coll. with C. L. Chaffer
Coordination of the NanoTumor Consortium, initiated on Dec. 2019
and until May 2023
(in coll. with P. Schultz & al.)
Towards the tumor cell atlas
F. Colin & al. (2021) - Bio. of the Cell
Thank you for your interest in our research.
Get in touch with us for any questions or comments regarding our work, publications and open positions
Jacky G. Goetz - GoetzLab Members
CRBS – Centre de Recherche en Biomédecine de Strasbourg
GoetzLab - U1109 - 5ème étage
1, rue Eugène Boeckel, 67000 Strasbourg